InterPro domain: IPR035082

Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [ 1 ]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [ 2 ].

This domain has a nucleotidyltransferase structure.

1. Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans. Genes Cells 7, 115-32