InterPro domain: IPR035009

This entry represents the RNA recognition motif (RRM) of SR140 (also known as U2SURP) which is a putative splicing factor mainly found in higher eukaryotes. Although it was initially identified as one of the 17S U2 snRNP-associated proteins, the molecular and physiological function of SR140 remains unclear [ 1 ]. SR140 contains an N-terminal RNA recognition motif (RRM), a SWAP/SURP domain that is found in a number of pre-mRNA splicing factors in the middle region, and a C-terminal arginine/serine-rich domain (RS domain).

Proteins containing this domain also include Arabidopsis RRC1, which is a splicing factor which is required for phytochrome B (phyB) signal transduction [ 2 ].

1. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J. 21, 4978-88
2. The RS domain of Arabidopsis splicing factor RRC1 is required for phytochrome B signal transduction. Plant J. 70, 727-38