InterPro domain: IPR034815

This is a diverse family of oxygenases related to the animal heme peroxidases, with members from plants, fungi, and bacteria. Plant alpha-dioxygenases 1 (DOX1), also known as pathogen-inducible oxygenase (PIOX), and DOX2 oxygenate fatty acids into 2R-hydroperoxides [ 1 , 2 , 3 ]. PIOX is expressed during the hypersensitive reaction, which is characterised by rapid and localised cell death induced by infection with pathogens, and the rapidly induced expression of PIOX may be caused by the oxidative burst that occurs in the process of cell death [ 4 ]. PIOX may protect plant tissues from oxidative stress and cell death [ 5 ].

1. Purification, crystallization and preliminary X-ray diffraction analysis of pathogen-inducible oxygenase (PIOX) from Oryza sativa. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62, 365-7
2. Involvement of the Arabidopsis alpha-DOX1 fatty acid dioxygenase in protection against oxidative stress and cell death. Plant J. 29, 61-2
3. Functional analysis of alpha-DOX2, an active alpha-dioxygenase critical for normal development in tomato plants. Plant Physiol. 151, 1421-32
4. PIOX, a new pathogen-induced oxygenase with homology to animal cyclooxygenase. Plant Cell 10, 1523-37