InterPro domain: IPR034804
General Information
- Identifier IPR034804
- Description Fumarate reductase/succinate dehydrogenase, transmembrane subunit
- Number of genes 154
- Gene duplication stats Loading...
- Associated GO terms GO:0016020
Abstract
Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalysed by the related complex II of the respiratory chain (succinate dehydrogenase) [ 1 ]. Succinate dehydrogenase (SQR) and fumarate reductase (QFR) share a common subunit arrangement, composed of a flavoprotein catalytic subunit (subunit A), an iron-sulfur protein (subunit B) and one or two hydrophobic transmembrane subunits (subunits C and D) [ 2 , 2 ].
This homologous superfamily includes the membrane components of both fumarate reductase and succinate dehydrogenase.
1. Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution. Nature 402, 377-85
2. Succinate: quinone oxidoreductases. Variations on a conserved theme. Biochim. Biophys. Acta 1320, 107-41