InterPro domain: IPR034604

General Information

  • Identifier IPR034604
  • Description Serine/Arginine-related protein 53
  • Number of genes 131
  • Gene duplication stats Loading...
  • Associated GO terms GO:0000380   GO:0000398  

Abstract

The SR (serine- and arginine-rich) family proteins and SR-related proteins are important regulators of pre-mRNA splicing. SRRP53 (for SR-related protein of 53kDa) is required in the second step of pre-mRNA splicing and also regulates alternative splicing in a concentration-dependent manner [ 1 ]. SRRP53, also known as RSRC1, may also be required for regulation of PIAS1-mediated estrogen receptor beta SUMOylation [ 2 ].


1. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Mol. Cell. Biol. 25, 2969-80
2. RSRC1 SUMOylation enhances SUMOylation and inhibits transcriptional activity of estrogen receptor β. FEBS Lett. 589, 1476-84

Species distribution

Gene table