InterPro domain: IPR034590
General Information
- Identifier IPR034590
- Description POLYCHOME/GIGAS CELL1
- Number of genes 193
- Gene duplication stats Loading...
- Associated GO terms GO:0005634 GO:0051783 GO:1904667
Abstract
This family of plant proteins includes POLYCHOME (UVI4, UV-B-INSENSITIVE 4) and its paralogue GIGAS CELL1 (GIG1 , UV-B-INSENSITIVE 4-like). GIG1 and UVI4 negatively regulate activities of anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. GIG1 and UVI4 may regulate endomitosis and endoreplication, preventing an unscheduled increase in cellular ploidy, by inhibiting APC/C in different ways [ 1 ]. They preferentially inhibit APC/C(CDC20) and APC/C(FZR), respectively [ 2 ].
1. Roles of GIG1 and UVI4 in genome duplication in Arabidopsis thaliana. Plant Signal Behav 7, 1079-81
2. GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis. Plant Cell 23, 4382-93