InterPro domain: IPR034561
General Information
- Identifier IPR034561
- Description Negative regulator of systemic acquired resistance SNI1
- Number of genes 124
- Gene duplication stats Loading...
- Associated GO terms GO:0005634 GO:0045892 GO:0030915 GO:0006974 GO:0031348
Abstract
SNI1 was isolated in a screen for negative regulators of NPR1, a transcriptional coactivator of plant pathogen defence gene PR1 [ 1 ]. SNl1 has been shown to cooperate with the transcription repressor CBNAC, which binds to cis-elements on the PR1 promoter, to suppress PR1 expression [ 2 ]. SNI1 also regulates DNA damage sensor proteins RAD17 and ATR, suggesting that DNA damage responses is an intrinsic component of the plant immune responses. SNI1 is a subunit of the Structural Maintenance of Chromosome (SMC) 5/6 complex involved in DNA damage responses [ 3 ].
1. Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1. Cell 98, 329-39
2. A NAC transcription factor and SNI1 cooperatively suppress basal pathogen resistance in Arabidopsis thaliana. Nucleic Acids Res. 40, 9182-92
3. Salicylic acid activates DNA damage responses to potentiate plant immunity. Mol. Cell 52, 602-10