InterPro domain: IPR034453

This entry represents the RNA recognition motif 1 (RRM1) of Mei2-like proteins.

Mei2-like proteins represent an ancient eukaryotic RNA-binding proteins family [ 1 ]. Their corresponding Mei2-like genes appear to have arisen early in eukaryote evolution, been lost from some lineages such as Saccharomyces cerevisiae and metazoans, and diversified in the plant lineage [ 2 ]. The plant Mei2-like genes may function in cell fate specification during development, rather than as stimulators of meiosis [ 3 , 4 ]. Members of the Mei2-like family contain three RNA recognition motifs (RRMs). The C-terminal RRM (RRM3) is unique to Mei2-like proteins and it is highly conserved between plants and fungi [ 5 ].

1. Functional cloning of a cDNA encoding Mei2-like protein from Arabidopsis thaliana using a fission yeast pheromone receptor deficient mutant. FEBS Lett. 413, 16-20
2. Diversification of genes encoding mei2 -like RNA binding proteins in plants. Plant Mol. Biol. 54, 653-70
3. The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth. BMC Plant Biol. 5, 2
4. The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis. Plant Cell 18, 545-59
5. A description of the Mei2-like protein family; structure, phylogenetic distribution and biological context. Dev. Genes Evol. 214, 149-58