InterPro domain: IPR034318

This entry includes transcriptional adapter ADA2 mostly from plants. There are two ADA2 proteins found in Arabidopsis, ADA2a and ADA2b. They are transcriptional coactivator proteins that interact with the histone acetyltransferase GCN5 and with the cold-induced transcription factor CBF1 [ 1 ]. Interestingly, ADA2b T-DNA mutations have pleiotropic effects on plant growth and development [ 2 ], while ADA2a mutants are indistinguishable from wild-type plants. They may have different roles in plants. ADA2b has been shown to be involved in abiotic stress responses including low temperature and salt stress [ 3 ].

1. Physical and functional interactions of Arabidopsis ADA2 transcriptional coactivator proteins with the acetyltransferase GCN5 and with the cold-induced transcription factor CBF1. Biochim. Biophys. Acta 1759, 69-79
2. Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development, and gene expression. Plant Cell 15, 626-38
3. The role of transcriptional coactivator ADA2b in Arabidopsis abiotic stress responses. Plant Signal Behav 6, 1475-8