InterPro domain: IPR034261

This entry represents the RNA recognition motif (RRM) of NOT4 (also known as CNOT4), which is a component of the CCR4-NOT complex, a global negative regulator of RNA polymerase II transcription [ 1 ]. NOT4 functions as an ubiquitin-protein ligase (E3) [ 2 ]. It contains an N-terminal C4C4 type RING finger motif, followed by a RNA recognition motif (RRM). The RING fingers may interact with a subset of ubiquitin-conjugating enzymes (E2s), including UbcH5B, and mediate protein-protein interactions [ 3 ].

1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res. 28, 809-17
2. An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. J. Mol. Biol. 337, 157-65
3. Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches. Structure 12, 633-44