InterPro domain: IPR034257

This entry represents the RNA recognition motif (RRM) of Acinus (called 'Apoptotic chromatin condensation inducer in the nucleus' or ACIN1). Acinus was first identified as a target of proteolytic cleavage during apoptosis and has been implicated in transcriptional control [ 1 ]. Later, it was found to be part of the ASAP complex (consists of Acinus, RNPS1 and SAP18) that interacts with the exon-junction complex (EJC), a messenger ribonucleoprotein complex involved in post-transcriptional regulation. The ASAP complex serves as an auxiliary component of EJC deposited at splice junction on mRNAs [ 2 , 3 ]. Acinus contains a P-loop motif and an RNA recognition motif (RRM).

1. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 401, 168-73
2. Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Mol. Cell. Biol. 32, 954-67
3. The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Nat. Struct. Mol. Biol. 19, 378-86