InterPro domain: IPR034254

The entry represents the RNA recognition motif (RRM) of eukaryotic DnaJ homologue subfamily C member 17 (DNAJC17) and similar proteins [ 1 ]. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family [ 2 ].

DNAJC17 may negatively affect PAX8-induced thyroglobulin/TG transcription [ 3 ]. It contains an N-terminal DnaJ domain or J-domain, which mediates the interaction with Hsp70 [ 4 ], and a RNA recognition motif (RRM) at the C terminus.

1. Eukaryotic DnaJ homologs and the specificity of Hsp70 activity. Cell 74, 5-6
2. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. Cell. Mol. Life Sci. 63, 2560-70
3. A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid. Endocrinology 151, 1948-58
4. DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70. Trends Biochem. Sci. 19, 176-81