InterPro domain: IPR034219

ZCRB1 is a novel multi-functional nuclear factor that may be involved in morphine dependence, cold/heat stress, and hepatocarcinoma. It is located in the nucleoplasm, but outside the nucleolus [ 1 ]. ZCRB1 is one of the components of U11/U12 snRNPs that bind to U12-type pre-mRNAs and form a di-snRNP complex, simultaneously recognizing the 5' splice site and branchpoint sequence [ 2 , 3 ]. ZCRB1 is characterised by an RNA recognition motif (RRM), and a CCHC-type zinc finger motif. In addition, it contains core nucleocapsid motifs, and Lys- and Glu-rich domains.

This entry represents the RNA recognition motif (RRM) of ZCRB1.

1. Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. Genomics 89, 59-69
2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA 10, 929-41
3. The Arabidopsis U12-type spliceosomal protein U11/U12-31K is involved in U12 intron splicing via RNA chaperone activity and affects plant development. Plant Cell 22, 3951-62