InterPro domain: IPR034122
General Information
- Identifier IPR034122
- Description Retropepsin-like domain, bacterial
- Number of genes 17
- Gene duplication stats Loading...
Abstract
This entry includes bacterial aspartate proteases that are retropepsin-like, i.e. like the enzymes from retrovirus and retrotransposons. While fungal and mammalian pepsin-like aspartate proteases are bilobal proteins with structurally related N- and C-termini, this family of bacteria aspartate proteases is half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. In aspartate peptidases, Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate proteases is classified by MEROPS as the peptidase family A32. The RC1339/APRc protein from Rickettsia conorii has been characterized [ 1 ] and its tertiary structure determined [ 2 ].
1. RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes. PLoS Pathog. 10, e1004324
2. Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease. Acta Crystallogr. D Biol. Crystallogr. 71, 2109-18