InterPro domain: IPR034095

General Information

  • Identifier IPR034095
  • Description NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
  • Number of genes 110
  • Gene duplication stats Loading...
  • Associated GO terms GO:0032981  

Abstract

Human NDUFAF3 (C3ORF60) protein is an essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). It interacts with complex I subunits [ 1 ].


1. Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease. Am. J. Hum. Genet. 84, 718-27

Species distribution

Gene table