InterPro domain: IPR034078

This family of transcription factors is conserved from yeast to human. It is named after human NF-X1, a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes [ 1 , 2 ]. The Drosophila homologue shuttle craft (STC) has been shown to be a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system [ 3 ] and the yeast homologue FAP1 encodes a dosage suppressor of rapamycin toxicity [ 4 ].

1. A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor. J. Exp. Med. 180, 1763-74
2. The major histocompatibility complex class II promoter-binding protein RFX (NF-X) is a methylated DNA-binding protein. Mol. Cell. Biol. 13, 6810-8
3. A homolog of human transcription factor NF-X1 encoded by the Drosophila shuttle craft gene is required in the embryonic central nervous system. Mol. Cell. Biol. 16, 192-201
4. FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast. Mol. Microbiol. 37, 1480-93