InterPro domain: IPR034014
General Information
- Identifier IPR034014
- Description Pol III subunit C11, C-terminal zinc ribbon
- Number of genes 102
- Gene duplication stats Loading...
- Associated GO terms GO:0042779
Abstract
The C-terminal zinc ribbon domain of subunit C11 in RNA polymerase (Pol) III (RPC11) is required for intrinsic transcript cleavage. RPC11 is also involved in Pol III termination [ 1 ]. Eukaryote genomes are transcribed by three nuclear RNA polymerases (Pol I, II and III) that share some subunits. RPC11 is homologous to RPB9 of Pol II and RPA12 of Pol I. RPC11 C-terminal zinc ribbon is homologous to Pol II elongation factor TFIIS domain III [ 2 , 3 ]. RPC11 has two zinc-binding domains separated by a flexible linker [ 4 ].
1. Transcription termination by the eukaryotic RNA polymerase III. Biochim. Biophys. Acta 1829, 318-30
2. Evolution of two modes of intrinsic RNA polymerase transcript cleavage. J. Biol. Chem. 286, 18701-7
3. The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination. Genes Dev. 12, 3857-71