InterPro domain: IPR034004

General Information

  • Identifier IPR034004
  • Description Pol I subunit A12, C-terminal zinc ribbon
  • Number of genes 109
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006379  

Abstract

The C-terminal zinc ribbon domain of subunit A12 in RNA polymerase (Pol) I (RPA12) is involved in intrinsic transcript cleavage [ 1 , 2 ]. Eukaryote genomes are transcribed by three nuclear RNA polymerases (Pol I, II and III) that share some subunits. RPA12 in Pol I, RPB9 in Pol II, RPC11 in Pol III and TFS in archaea are distantly related to each other and to the TFIIS elongation factor of Pol II [ 3 ]. RPA12 has two zinc-binding domains separated by a flexible linker [ 3 ].


1. Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p. Proc. Natl. Acad. Sci. U.S.A. 101, 6068-73
2. Evolution of two modes of intrinsic RNA polymerase transcript cleavage. J. Biol. Chem. 286, 18701-7
3. Rpa12p, a conserved RNA polymerase I subunit with two functional domains. Mol. Microbiol. 43, 1105-13

Species distribution

Gene table