InterPro domain: IPR033961
General Information
- Identifier IPR033961
- Description Exocyst complex component Exo84
- Number of genes 485
- Gene duplication stats Loading...
- Associated GO terms GO:0006887 GO:0000145
Abstract
The exocyst is a highly conserved complex composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84, which was originally identified in Saccharomyces cerevisiae [ 1 ]. Mammalian homologues of all eight exocyst proteins have been identified [ 2 ]. The exocyst is required for exocytosis; it mediates tethering of the secretory vesicle before docking and fusion with the plasma membrane [ 3 ].
Exo84 is also involved in pre-mRNA splicing [ 4 ] and is required for epithelial polarity in Drosophila [ 5 , 6 ].
1. The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J. 15, 6483-94
2. Identification and characterization of homologues of the Exocyst component Sec10p. FEBS Lett. 404, 135-9
3. The Exocyst Complex in Health and Disease. Front Cell Dev Biol 4, 24
4. New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. J. Biol. Chem. 276, 31004-15
5. The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity. J. Cell. Sci. 120, 3099-110
6. Crumbs stabilises epithelial polarity during tissue remodelling. J. Cell. Sci. 122, 2604-12