InterPro domain: IPR033948
General Information
- Identifier IPR033948
- Description Electron transfer flavoprotein, beta subunit, N-terminal
- Number of genes 113
- Gene duplication stats Loading...
Abstract
This entry refers to an N-terminal domain found predominantly in the beta subunit of ETF.
The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase [ 1 ]. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer. A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit [ 2 ].
1. Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution. Proc. Natl. Acad. Sci. U.S.A. 93, 14355-60
2. Phylogenetic characterization of the ubiquitous electron transfer flavoprotein families ETF-alpha and ETF-beta. Res. Microbiol. 146, 397-404