InterPro domain: IPR033788
General Information
- Identifier IPR033788
- Description Antitoxin VbhA-like
- Number of genes 3
- Gene duplication stats Loading...
- Associated GO terms GO:1900723
Abstract
VbhA is the antitoxin to VbhT. VbhT is a toxin of the mammalian pathogen Bartonella schoenbuchensis responsible for the disruptive adenylation of host proteins [ 1 ]. VbhT is composed of an N-terminal FIC domain and a C-terminal BID domain. VbhT also induces FIC-domain-mediated growth arrest in bacteria. It is inhibited by this antitoxin which binds to block the ATP binding site of the VbhT FIC domain [ 2 ]. The antitoxin is related to an N-terminal domain in several Fic family proteins [ 3 ].
1. Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. Nature 482, 107-10
2. Bacterial FIC Proteins AMP Up Infection. Sci Signal 2, pe14
3. Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with Fic fold. PLoS ONE 8, e64901