InterPro domain: IPR033771

Rrp44 (also known as Dis3) constitutes the only active nuclease of the yeast exosome core [ 1 ]. The structure of Rrp44 consists of CSD1, CSD2, RNB, and S1 domains. The two N-terminal cold shock domains (CSD1 and CSD2) and the C-terminal S1 domain all display characteristic OB folds [ 2 ]. This entry represents CSD1.

1. A single subunit, Dis3, is essentially responsible for yeast exosome core activity. Nat. Struct. Mol. Biol. 14, 15-22
2. Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family. Mol. Cell 29, 717-28