InterPro domain: IPR033740
General Information
- Identifier IPR033740
- Description Aminopeptidase P
- Number of genes 241
- Gene duplication stats Loading...
- Associated GO terms GO:0070006
Abstract
This entry represents the catalytic domain of aminopeptidases P, which are members of peptidase subfamily M24B, including aminopeptidases P1 (MEROPS identifier M24.005) and P2 (M24.009), both of which are assigned to E.C. 3.4.11.9. The enzymes are also known as X-Pro aminopeptidases, proline aminopeptidases and aminoacylproline aminopeptidases. They catalyse release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide [ 1 , 2 , 3 ].
1. Proline specific peptidases. Biochim. Biophys. Acta 1343, 160-86
2. Metalloaminopeptidases: common functional themes in disparate structural surroundings. Chem. Rev. 102, 4581-608
3. Evolutionary families of metallopeptidases. Meth. Enzymol. 248, 183-228