InterPro domain: IPR033728

Threonyl-tRNA synthetase (ThrRS) is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. ThrRS is a homodimer. This core domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. ThrRS has been assigned to class II based upon its structure and the presence of three characteristic sequence motifs in the core domain [ 1 , 2 , 3 , 4 ].

1. Eleven down and nine to go. Nat. Struct. Biol. 2, 824-31
2. Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. Genome Res. 9, 689-710
3. Genomics and the evolution of aminoacyl-tRNA synthesis. Acta Biochim. Pol. 48, 313-21
4. On the evolution of structure in aminoacyl-tRNA synthetases. Microbiol. Mol. Biol. Rev. 67, 550-73