InterPro domain: IPR033719
General Information
- Identifier IPR033719
- Description N-acetylglutamate synthase, kinase-like domain
- Number of genes 151
- Gene duplication stats Loading...
Abstract
This is the N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. The domain architecture of these NAGS consists of an N-terminal NAG kinase-like (ArgB) domain and a C-terminal NAG synthase, acetyltransferase (ArgA) domain. Both bacterial and plant sequences have a conserved N-terminal extension; a similar sequence in the NAG kinases of the cyclic arginine-biosynthesis pathway has been implicated in feedback inhibition sensing. Plant sequences also have an N-terminal chloroplast transit peptide and an insert (approx. 70 residues) in the C-terminal region of ArgB [ 1 , 2 ].
1. N-acetylglutamate and its changing role through evolution. Biochem. J. 372, 279-90
2. Genes, enzymes and regulation of arginine biosynthesis in plants. Plant Physiol. Biochem. 43, 729-45