InterPro domain: IPR033714
General Information
- Identifier IPR033714
- Description Phenylalanly tRNA synthetase, tRNA-binding-domain
- Number of genes 4
- Gene duplication stats Loading...
- Associated GO terms GO:0000049
Abstract
This entry represents the tRNA-binding-domain of prokaryotic phenylalanyl tRNA synthetase (PheRS) beta chain. PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs), but because they aminoacylate the 2'OH of the terminal ribose of tRNA, they belong functionally to class I aaRSs. PheRS adopts the alpha2beta2 tetrameric structure in prokaryotic and eukaryotic cytoplasmic enzymes [ 1 ], with both subunits required for aminoacylation of the tRNA. All four subunits in the tetramer interact with each other and with both bound tRNA substrates [ 2 , 3 ]. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme [ 4 ].
1. Aminoacyl-tRNA synthetases in biology and disease: new evidence for structural and functional diversity in an ancient family of enzymes. RNA 3, 954-60
2. The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe. Structure 5, 59-68
3. Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus. Nat. Struct. Biol. 2, 537-47