InterPro domain: IPR033709

General Information

  • Identifier IPR033709
  • Description Isoleucyl tRNA synthetase type 2, anticodon-binding domain
  • Number of genes 141
  • Gene duplication stats Loading...
  • Associated GO terms GO:0000049  

Abstract

This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. It is found in bacterial, archaeal, and eukaryotic IleRS proteins. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA [ 1 ].


1. Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase. J. Biol. Chem. 276, 47387-93

Species distribution

Gene table