InterPro domain: IPR033570

SCNM1 (sodium channel modifier 1) is an accessory component of the U1 splicesome protein complex. It interacts with the spliceosomal Sm and U1-70K proteins and has a direct role in splicing [ 1 ]. It was originally identified as a disease modifier gene required for efficient splicing of a mutant splice donor site in the sodium channel Scn8a [ 2 ].

1. Evidence for a direct role of the disease modifier SCNM1 in splicing. Hum. Mol. Genet. 16, 2506-16
2. SCNM1, a putative RNA splicing factor that modifies disease severity in mice. Science 301, 967-9