InterPro domain: IPR033495

General Information

  • Identifier IPR033495
  • Description Mitochondrial ribonuclease P catalytic subunit
  • Number of genes 6
  • Gene duplication stats Loading...
  • Associated GO terms GO:0008033   GO:0005739  

Abstract

MRPP3 is part of mitochondrial ribonuclease P (mt-RNase P) that cleaves tRNA molecules in their 5'-ends [ 1 ]. In humans, mt-RNase P is composed of three protein subunits (MRPP1-3) and is only active as a tripartite complex. MRPP1 and MRPP2 deliver the pre-tRNA substrate and activate MRPP3 [ 2 ].


1. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell 135, 462-74
2. Structure of the nuclease subunit of human mitochondrial RNase P. Nucleic Acids Res. 43, 5664-72

Species distribution

Gene table