InterPro domain: IPR033468
General Information
- Identifier IPR033468
- Description Metaxin, glutathione S-transferase domain
- Number of genes 141
- Gene duplication stats Loading...
Abstract
This entry represents a conserved glutathione S-transferase (GST) domain present in metaxins [ 1 , 2 ] and failed axon connections (FAX). Metaxin is a mitochondrial outer membrane protein, which is involved in transport of proteins into the mitochondrion [ 3 ]. FAX may play a role in axonal development [ 4 ].
1. The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. Gene 330, 67-73
2. Characterization of the cDNA and amino acid sequences of Xenopus Metaxin 3, and relationship to Xenopus Metaxins 1 and 2. DNA Seq. 16, 252-9
3. Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex. Biochem. Biophys. Res. Commun. 276, 1028-34
4. Genetic interactions between the Drosophila Abelson (Abl) tyrosine kinase and failed axon connections (fax), a novel protein in axon bundles. Genetics 141, 595-606