InterPro domain: IPR033464

This domain is conserved from fungi, plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome) where it functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development [ 1 ]. It is found in Eukaryotic translation initiation factor 3 subunit K, a component of the eukaryotic translation initiation factor 3 (eIF-3) complex required for the initiation of protein synthesis [ 2 ]. It is also found in 26S proteasome non-ATPase regulatory subunit 8 (PSMD8), a regulatory subunit of the 26S proteasome [ 3 ].

1. Gene structure and embryonic expression of mouse COP9 signalosome subunit 8 (Csn8). Gene 321, 65-72
2. Reconstitution reveals the functional core of mammalian eIF3. EMBO J. 26, 3373-83
3. Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. EMBO J. 14, 3105-15