InterPro domain: IPR033378

Protein BRICK1 (Brk1) is part of the WAVE/SCAR complex, which links upstream Rho-GTPase signalling to the activation of the Arp2/3-complex and mediates actin nucleation [ 1 , 2 ]. Brk1 is the only subunit for which a major pool is not associated with the WAVE/SCAR complex [ 3 ]. This free pool of Brk1 is composed of an homotrimer and is a critical precursor for the assembly of the WAVE/SCAR complex [ 4 , 5 ]. Brk1 is required for embryonic development and cell transformation [ 6 ].

1. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat. Rev. Mol. Cell Biol. 8, 37-48
2. Structure and control of the actin regulatory WAVE complex. Nature 468, 533-8
3. Purification and architecture of the ubiquitous Wave complex. Proc. Natl. Acad. Sci. U.S.A. 101, 4379-83
4. Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS ONE 3, e2462
5. High-resolution X-ray structure of the trimeric Scar/WAVE-complex precursor Brk1. PLoS ONE 6, e21327
6. Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Cancer Res. 70, 9349-59