InterPro domain: IPR033370
General Information
- Identifier IPR033370
- Description Conserved oligomeric Golgi complex subunit 1
- Number of genes 176
- Gene duplication stats Loading...
- Associated GO terms GO:0017119 GO:0006891
Abstract
The conserved oligomeric Golgi complex (COG) is a peripheral membrane protein complex involved in intra-Golgi protein trafficking. The complex is composed of eight subunits that are located in two lobes; Lobe A contains COG1-4, and Lobe B is composed of COG5-8. COG1 and COG8 are required for the stable association between two COG subcomplexes [ 1 , 2 , 3 ].
1. Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. J. Biol. Chem. 280, 27613-23
2. Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells. J. Biol. Chem. 280, 32736-45
3. A new inborn error of glycosylation due to a Cog8 deficiency reveals a critical role for the Cog1-Cog8 interaction in COG complex formation. Hum. Mol. Genet. 16, 717-30