InterPro domain: IPR033346

AIM1 is a multifunctional protein involved in peroxisomal fatty acid beta-oxidation. It possesses enoyl-CoA hydratase activity against short chain substrates (C4-C6) and 3-hydroxyacyl-CoA dehydrogenase activity against chains of variable sizes (C6-C16) [ 1 , 2 , 3 ]. It also possesses cinnamoyl-CoA hydratase activity and is involved in the peroxisomal beta-oxidation pathway for the biosynthesis of benzoic acid (BA) [ 4 ].

This entry represents 3-hydroxyacyl-CoA dehydrogenases such as peroxisomal fatty acid beta-oxidation multifunctional protein AIM1 and related peroxisomal fatty acid beta-oxidation multifunctional proteins.

1. A defect in beta-oxidation causes abnormal inflorescence development in Arabidopsis. Plant Cell 11, 1911-24
2. Jasmonate biosynthesis in Arabidopsis thaliana requires peroxisomal beta-oxidation enzymes--additional proof by properties of pex6 and aim1. Phytochemistry 68, 1642-50
3. The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2. J. Biol. Chem. 285, 24066-77
4. Peroxisomal ATP-binding cassette transporter COMATOSE and the multifunctional protein abnormal INFLORESCENCE MERISTEM are required for the production of benzoylated metabolites in Arabidopsis seeds. Plant Physiol. 164, 48-54