InterPro domain: IPR033341
General Information
- Identifier IPR033341
- Description Spindle and kinetochore-associated protein 3
- Number of genes 106
- Gene duplication stats Loading...
- Associated GO terms GO:0007059 GO:0000940
Abstract
The Ska complex is an essential mitotic component required for accurate cell division in human cells. It is an important kinetochore component involved in the formation of kinetochore-microtubule interactions, and together with the Ndc80 complex couples chromosome movement to microtubule depolymerization [ 1 ]. The complex is composed of three subunits: Ska1, Ska2, and Ska3.
Ska3 was the last subunit of the complex identified [ 2 ]. Ska3 accumulates on kinetochores in prometaphase after nuclear envelope breakdown. During mitosis, it is required for the maintenance of chromosome cohesion and may play an important role in silencing the spindle checkpoint [ 3 ].
1. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Dev. Cell 16, 374-85
2. Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. EMBO J. 28, 1442-52
3. Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis. Curr. Biol. 19, 1467-72