InterPro domain: IPR033317
General Information
- Identifier IPR033317
- Description Transcription-associated protein 1
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0005634 GO:0016573 GO:0000123
Abstract
This entry includes transcription-associated protein 1 (Tra1) from yeasts and TRRAP from mammals. Budding yeast Tra1 is a subunit of SAGA and NuA4 histone acetyltransferase complexes [ 1 , 2 ]. Human TRRAP is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT) [ 3 ].
1. The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol. Cell 2, 863-7
2. Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292, 2333-7
3. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol. Cell. Biol. 24, 1884-96
Species distribution
Gene table
Loading...