InterPro domain: IPR033257
General Information
- Identifier IPR033257
- Description N-acetyltransferase Eco1/Protein CHROMOSOME TRANSMISSION FIDELITY 7
- Number of genes 132
- Gene duplication stats Loading...
- Associated GO terms GO:0007062 GO:0016407 GO:0045132 GO:0000070
Abstract
This entry also includes the Eco1 homologue, Protein CHROMOSOME TRANSMISSION FIDELITY 7 (CTF7) from plants. CTF7 is essential for the establishment of sister chromatid cohesion during S phase of the cell cycle [ 1 ].
Budding yeast Eco1 is required for establishment of sister chromatid cohesion during S phase but not for its further maintenance during G2 or M phases or for loading the cohesin complex onto DNA [ 2 ]. It exhibits acetyltransferase activity [ 3 ].
1. Overexpression of a truncated CTF7 construct leads to pleiotropic defects in reproduction and vegetative growth in Arabidopsis. BMC Plant Biol. 15, 74
2. Mechanical link between cohesion establishment and DNA replication: Ctf7p/Eco1p, a cohesion establishment factor, associates with three different replication factor C complexes. Mol. Cell. Biol. 23, 2999-3007
3. Ctf7p/Eco1p exhibits acetyltransferase activity--but does it matter? Curr. Biol. 15, R50-1