InterPro domain: IPR033253

General Information

  • Identifier IPR033253
  • Description Cilia- and flagella-associated protein 45
  • Number of genes 6
  • Gene duplication stats Loading...

Abstract

Cilia- and flagella-associated protein 45, also known as coiled-coil domain-containing protein 19 (CCDC19) or nasopharyngeal epithelium specific protein (NESG1), has been identified in humans as a tumour suppressor [ 1 , 2 ]. It activates the expression of miR-184, which suppresses the expression of C-Myc, a key oncogenic transcription factor.


1. Potential tumor suppressor NESG1 as an unfavorable prognosis factor in nasopharyngeal carcinoma. PLoS ONE 6, e27887
2. Candidate tumour suppressor CCDC19 regulates miR-184 direct targeting of C-Myc thereby suppressing cell growth in non-small cell lung cancers. J. Cell. Mol. Med. 18, 1667-79

Species distribution

Gene table