InterPro domain: IPR033246
General Information
- Identifier IPR033246
- Description DNA-binding protein BIN4
- Number of genes 125
- Gene duplication stats Loading...
- Associated GO terms GO:0009330 GO:0003690 GO:0042023
Abstract
BIN4 (also known as MIDGET) is a plant-specific, DNA binding protein that acts as a component of the plant DNA topoisomerase VI complex. BIN4 is required for endoreduplication [ 1 ]. Loss of BIN4 triggers an ATM- and ATR-dependent DNA damage response in postmitotic cells, and this response coincides with the upregulation of the cyclin B1;1 gene, suggesting a functional link between DNA damage response and endocycle control [ 2 , 2 ].
1. BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis. Plant Cell 19, 3655-68
2. MIDGET unravels functions of the Arabidopsis topoisomerase VI complex in DNA endoreduplication, chromatin condensation, and transcriptional silencing. Plant Cell 19, 3100-10