InterPro domain: IPR033101

General Information

  • Identifier IPR033101
  • Description RNA-binding protein 45
  • Number of genes 2
  • Gene duplication stats Loading...

Abstract

RNA-binding protein 45 (RBM45), also known as Drb1, is a neural RNA-binding protein that forms cytoplasmic inclusions in neurons and glia in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) [ 1 , 2 ]. It may function as a homo-oligomer and its oligomerization contributes to ALS/FTLD RNA-binding protein aggregation [ 3 ].


1. cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein. Biochem. Biophys. Res. Commun. 297, 96-104
2. RBM45 homo-oligomerization mediates association with ALS-linked proteins and stress granules. Sci Rep 5, 14262

Species distribution

Gene table