InterPro domain: IPR033100

The conserved core of the exosome complex, the major eukaryotic 3' --> 5' exonuclease, consists of nine subunits that form a ring similar to the phosphorolytic bacterial PNPase and archaeal exosome [ 1 , 2 ]. The complex functions in the accurate processing of nuclear RNA precursors and in the degradation of RNAs in both the nucleus and the cytoplasm [ 3 ].

Rrp45, also known as EXOSC9, is a core component of the RNA exosome complex which participates in a multitude of cellular RNA processing and degradation events [ 4 ].

1. A single subunit, Dis3, is essentially responsible for yeast exosome core activity. Nat. Struct. Mol. Biol. 14, 15-22
2. Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell 127, 1223-37
3. RNA-quality control by the exosome. Nat. Rev. Mol. Cell Biol. 7, 529-39
4. The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. Genes Dev. 13, 2148-58