InterPro domain: IPR033060

General Information

  • Identifier IPR033060
  • Description Integrator complex subunit 7
  • Number of genes 145
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016180   GO:0032039  

Abstract

Integrator complex subunit 7 (INTS7) is a component of the integrator complex, a complex that is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of the largest subunit of RNA-polymerase II to promote 3'-snRNA processing [ 1 ]. In zebrafish, C. elegans and Drosophila, INTS7 has been found to be essential for normal development [ 2 , 3 , 4 , 5 ].


1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell 123, 265-76
2. Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nat. Genet. 31, 135-40
3. Identification of zebrafish insertional mutants with defects in visual system development and function. Genetics 170, 245-61
4. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421, 231-7
5. Phenotypic analysis of deflated/Ints7 function in Drosophila development. Dev. Dyn. 238, 1131-9

Species distribution

Gene table