InterPro domain: IPR033052

General Information

  • Identifier IPR033052
  • Description Cmr1/WDR76
  • Number of genes 126
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006974  

Abstract

This entry includes Cmr1 from fungi and WDR76 (WD repeat-containing protein 76) from animals. Cmr1 is a DNA-binding protein that binds to both single- and double-stranded DNA. It shows higher affinity to UV-damaged DNA substrates and is involved in the response to DNA replication stress in yeast [ 1 , 2 ]. Similar to Cmr1, WDR76 plays a role in the recovery from genotoxic stress through regulation of the turnover of sumoylated and phosphorylated proteins [ 3 ].


1. Saccharomyces cerevisiae Cmr1 protein preferentially binds to UV-damaged DNA in vitro. J. Microbiol. 50, 112-8
2. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. Nat Commun 6, 6533

Species distribution

Gene table