InterPro domain: IPR032861

This entry represents a domain found N-terminal in some aspartic proteinases and in xylanase inhibitors. The N- and C-termini of xylanase inhibitor proteins are join to create the catalytic pocket necessary for cleaving xylanase. Phytopathogens produce xylanase that destroys plant cells, so its destruction through proteolysis is vital for plant-survival [ 1 , 2 , 3 ].

1. Molecular identification of wheat endoxylanase inhibitor TAXI-I1, member of a new class of plant proteins. FEBS Lett. 540, 259-63
2. Structural basis for inhibition of Aspergillus niger xylanase by triticum aestivum xylanase inhibitor-I. J. Biol. Chem. 279, 36022-8
3. Identification of structural determinants for inhibition strength and specificity of wheat xylanase inhibitors TAXI-IA and TAXI-IIA. FEBS J. 276, 3916-27