InterPro domain: IPR032830

General Information

  • Identifier IPR032830
  • Description Helicase XPB/Ssl2, N-terminal domain
  • Number of genes 162
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Abstract

This domain is found in the N-terminal region of XPB/Ssl2. XPB/Ssl2 is a component of RNA polymerase transcription factor TFIIH holoenzyme required for DNA unwinding during transcription initiation [ 1 ]. It plays a dual role in transcription and DNA repair [ 2 ].


1. Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation. Proc. Natl. Acad. Sci. U.S.A. 112, 3961-6
2. XPB: An unconventional SF2 DNA helicase. Prog. Biophys. Mol. Biol. 117, 174-81

Species distribution

Gene table