InterPro domain: IPR032788

This entry represents the central domain of the glycogen debranching enzyme AGL. AGL is a multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation [ 1 ]. This central domain follows the glucanotransferase domain and precedes the glucosidase domain. By analogy with baterial GDEs (glycogen debranching enzymes), this domain may be involved in substrate binding either for the N-terminal glucanotransferase and/or the C-terminal glucosidase (or both).

1. The Saccharomyces cerevisiae fermentation stress response protein Igd1p/Yfr017p regulates glycogen levels by inhibiting the glycogen debranching enzyme. FEMS Yeast Res. 11, 499-508