InterPro domain: IPR032641

General Information

  • Identifier IPR032641
  • Description Exonuclease 1
  • Number of genes 138
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006281   GO:0035312  

Abstract

This entry represents exonuclease 1 (Exo1) from eukaryotes. Exo1 is a 5'-3' exonuclease that functions in DNA mismatch repair (MMR), double-strand break repair, replication and recombination [ 1 , 2 , 3 ]. It also possesses a flap-endonuclease activity [ 4 , 4 ].

Budding yeast Exo1 has a paralogue known as Din7, which is involved in mitochondrial DNA repair and replication [ 5 ].


1. Reconstitution of 5'-directed human mismatch repair in a purified system. Cell 122, 693-705
2. Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA. Oncogene 23, 1457-68
3. Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae. DNA Repair (Amst.) 1, 895-912
4. The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities. J. Biol. Chem. 274, 37763-9
5. Enhanced expression of the DNA damage-inducible gene DIN7 results in increased mutagenesis of mitochondrial DNA in Saccharomyces cerevisiae. Mol. Genet. Genomics 269, 632-9

Species distribution

Gene table