InterPro domain: IPR032567

This family includes mammalian retrotransposon-derived proteins from the Mart family: LDOC1/Mart7, LDOC1L/Mart6, RTL1/Mart1, PEG10/Mart2, FAM127/Cxx1/Mart8, ZCCHC5/Mart3, Zcchc16/Mart4, RGAG4/Mart5 [ 1 , 2 ] and related retrotransposon Gag-like proteins. Sirh7/LDOC1 (sushi-ichi retrotransposon homologue 7/leucine zipper, downregulated in cancer 1), also known as mammalian retrotransposon-derived 7 (Mart7), is one of these newly acquired genes from long terminal repeat (LTR) retrotransposons in mammals [ 3 ].

This family also includes retrotransposon Gag-like proteins and uncharacterised proteins from fungi.

1. A small family of sushi-class retrotransposon-derived genes in mammals and their relation to genomic imprinting. J. Mol. Evol. 61, 481-90
2. Selective expression of sense and antisense transcripts of the sushi-ichi-related retrotransposon--derived family during mouse placentogenesis. Retrovirology 12, 9
3. Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition. Development 141, 4763-71