InterPro domain: IPR032563
General Information
- Identifier IPR032563
- Description DAMP1, SANT/Myb-like domain
- Number of genes 146
- Gene duplication stats Loading...
Abstract
This domain, approximately 90 residues, is mainly found in DNA methyltransferase 1-associated protein 1 (DAMP1), which plays an important role in development and maintenance of genome integrity in various mammalian species [ 1 , 2 ]. It mainly consists of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif and shows a structural similarity with SANT domain and Myb DNA-binding domain, indicating it contains a putative DNA-binding site [ 3 ].
1. Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process. Genes Cells 14, 1347-57
2. Distinct roles of DMAP1 in mouse development. Mol. Cell. Biol. 31, 1861-9
3. The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB. Trends Biochem. Sci. 21, 87-8