InterPro domain: IPR032466

The structural landmark of the metallo-dependent hydrolases (the amidohydrolase superfamily) is a (beta/alpha)8-barrel fold with transition metal ions bound inside the barrel [ 1 , 2 ]. This enzyme group comprises hundreds of hydrolytic enzymes with a diverse spectrum of substrates and reactions. Members have mono- or binuclear active-site metal centres, and play key roles in many fundamental processes [ 3 , 4 ].

1. Evolution of function in (beta/alpha)8-barrel enzymes. Curr Opin Chem Biol 7, 252-64
2. Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold. Chem. Rev. 105, 4038-55
3. Structural and catalytic diversity within the amidohydrolase superfamily. Biochemistry 44, 6383-91
4. Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily. Biochemistry 44, 12728-36